The two volumes "Science of Synthesis: Multicomponent Reactions" critically review the state of the art of domino, sequential, and consecutive multicomponent reactions in what is a highly dynamic field. They serve as the basis for practical application to reach the goals of diversity-oriented synthesis, reaction design, and novel synthetic concepts. Content: Biginelli Reaction, Strecker Reaction, Hantzsch Pyridine Synthesis, Mannich Reaction, Petasis Reaction, Willgerodt-Kindler Reaction, Kabachnik-Fields Reaction, Passerini Reaction, Ugi Reaction, Gewald Reaction (Vol. 1); Michael Additions, Wittig Reactions, Cycloadditions, Reactions Involving an a,ß-Unsaturated Carbonyl Compound as Electrophilic Component with Electron-Deficient Alkynes as Electrophiles, Reactions with Cycloaddition as the Key Step, Boron-Mediated Multicomponent Reactions, Silicon-Mediated Multicomponent Reactions, Free-Radical Mediated Multicomponent Reactions, Metal-Mediated Multicomponent Reactions (Vol. 2).