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The concept of frailty offers a convenient way to introduce unobserved heterogeneity and associations into models for survival data. This book presents a comprehensive overview of the fundamental approaches in the area of frailty models.
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This puts a keen focus on the role of imaging and the need to clearly identify and understand this aspect of clinical trials. As the pharmaceutical, biotech and... Læs mere
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Precision medicine seeks to use data to construct principled, i.e., evidence-based, treatment strategies that dictate where, when,... Læs mere
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The proposed book will focus on practical issues in pharmaceutical/clinical research and development from both regulatory and scientific perspectives. The book will outline and clarify those issues that have been commonly misused in the subject area of regulatory science.
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Clinical trials require strategic thinking and innovative methods since some traditional methods are not adequate... Læs mere
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"Major updates to include SAS programs"--Preface.
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Methodologies in Biosimilar Product Development covers the practical and challenging issues that are commonly encountered during the development, review, and approval of a proposed biosimilar product.
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Single-arm phase II trial is a key component for developing advanced cancer drug and treatment to target therapy and immunotherapy in which time-to-event... Læs mere
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Written by internationally recognized experts, this CBT clinician's manual provides disorder... Læs mere
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Written by internationally recognized experts, this CBT clinician's manual provides disorder... Læs mere
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This book presents the data mining techniques with focus on likelihood ratio test (LRT) based methods for signal... Læs mere