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Written by one of the preeminent experts in the field, this book covers commonly encountered controversial statistical issues in clinical trials and,... Læs mere
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The authors focus on the properties of various lipopeptides which are produced as metabolites by bacteria and have... Læs mere
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Outlines the fundamental concepts and models of pharmacokinetics (PK) from a mathematical perspective based on clinically relevant parameters. This book covers the... Læs mere
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Cluster Randomised Trials, Second Edition explores the advantages of cluster randomisation, with special attention given to evaluating the effects of interventions against... Læs mere
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The book offers practical guidance on how to incorporate biomarker data analysis in clinical trial studies. The book discusses the appropriate statistical... Læs mere
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This book is the first to focus on Bayesian phase I–II clinical trials. It describes many problems with the conventional phase I–phase II paradigm and covers a large number of modern Bayesian phase I–II clinical trial designs.
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Focuses on analytical similarity assessment in biosimilar product development following the FDA’s recommended stepwise approach for... Læs mere
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Like the well-regarded and bestselling second edition, Sample Size Calculations in Clinical Research, Third Edition, presents statistical procedures for... Læs mere
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Response-adaptive designs, which aim to reduce the number of patients receiving inferior treatments, are popular in Phase III clinical trials. This book provides an overview of the research in this area.