Recent medical advances have opened up exciting new possibilities for antibodies as a key drug modality in diseases including cancer and neurodegenerative disorders. This updated second edition has detailed expert guidance on the latest methods and protocols.
This book covers key aspects related to the use of viral vectors in neurobiology, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain diseases.
Maintaining the high standards and detailed practical guidance of Springer's Methods in Molecular Biology series, this book has comprehensive, step-by-step protocols on the fast and reliable use of viruses to induce down-regulation of target gene expression.
These include methods and techniques to identify regulatory RNAs, characterizing the function and expression of regulatory RNAs in bacterial cells, RNA structure prediction, and interactions between regulatory RNAs and proteins.
This Methods in Molecular Biology(TM) volume offers methodologies enabling researchers to interrogate every aspect of mammalian oocyte development including recombination, meiotic maturation, oocyte substrate uptake, chromosomal segregation and fertilisation.
Plant Salt Tolerance: Methods and Protocols describes recent advances and techniques employed by researchers to understand the molecular and ionic basis of salinity tolerance and to investigate the mechanisms of salt stress perception and signalling in plants.
This Neuromethods series book surveys new genetic techniques for generating genetically encoded activity sensors used to investigate neuronal activity. Each chapter covers a specific sensor and its utilization, with key description and implementation advice.
A broad definition of a receptor is a specialized protein on or in a cell that recognizes and binds a specific ligand to undergo a conformational change, leading to a physiological response or change in cell function.
The second edition of p53 Protocols expands upon the first edition with progress in p53 research since the publication of the first edition.
This Methods in Molecular Biology(TM) book covers topics such as how to image the structure of plant ovules and embryos, tools for establishing cell lineages, methods for studying the totipotency of plant cells, fluorescence-activated cell sorting and more.
The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis.
This book explores new protocols and features revised and improved methodologies, making it a valuable reference for all those contemplating a move into the study of intracellular Ca2+. It features lab-ready procedures and includes key implementation advice.