This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches... Læs mere
This volume provides comprehensive information and detailed laboratory protocols used in the study of prion diseases. Chapters also provide readers with detailed information about kuru, the clinical description of prion diseases, and the detection of prion protein and biomarkers.
There are detailed methods on leading techniques for stem cell genetic engineering and intra-organ transplantation for research and therapeutic purposes, in vivo imaging of donor stem cells, and essential requirements for setting up a new stem cell laboratory.
Here are techniques for modeling and assessing motor function in experimental animals from lower orders through vertebrates to mammals. Vol. II covers basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems and spinal cord systems.
Transcriptomics and proteomics are increasingly deployed in a variety of investigations, including research into brain disorders. Cutting-edge and highly practical, this book sets out easily reproducible methods of both gene- and protein expression profiling.
As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important.
This illustrated guide to the role of the forensic anthropologist in investigating child abuse is an essential resource in one of the most contentious areas of forensic pathology.
This exploration of topics from immunohistochemistry for multiple neurochemicals covers a range of vital techniques from detecting expression levels of neurochemicals, to identifying polysynaptic pathways and recognizing functional changes in vivo.
Animal models of schizophrenia and other major psychiatric disorders have been sought for decades and we now face new vistas on pathophysiology. Covering the key areas of research, this book explores the use of animal models in this difficult area of study.
Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi).