This volume highlights the role of proteostasis in human health and associated disease model systems, reflecting its rising importance which has led to the development of new technologies to obtain insight into underling protein mechanistic events.
The NuclearReceptor Superfamily, Second Edition will benefit those starting out in thenuclear receptor research field as well as to more established researchers whowish to apply different methods to a particular receptor or research problem.
This volumepresents detailed laboratory protocols for invitro synthesis of mRNA with favorable properties, its introduction intocells by a variety of techniques, and the measurement of physiological andclinical consequences such as protein replacement and cancer immunotherapy.
This volume provides a comprehensive collection of classical and cutting edge protocols and techniques to examine the normal development and physiological functions of the gastrointestinal system and to model the most common digestive diseases.
Written by leading experts in the field, chapters cover topics such as techniques to derive novel antimicrobial targets, methods of interpreting... Læs mere
This volume offers cutting-edge technologies for studies of gene regulation. The chapters include introductions to their respective topics, lists of the necessary materials and reagents, and step-by-step, readily reproducible laboratory protocols.
This book reviews technologies for studying organisms in situ, detailing the use of ecogenomic sensors in the ocean for monitoring of pathogens and biotoxins; documenting species diversity, evolution and function; studying aquatic organisms and more.
Stem cell research has achieved much, yet still faces many challenges. In this comprehensive handbook, experts provide step-by-step, proven protocols allowing both novices and experienced researchers to make a comparative assessment--and avoid common pitfalls.
Over the last decade the development of new molecular biology tools, advanced microscopy, live imaging and systems biology approaches have revolutionized our conception of how embryonic development proceeds.
The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.